The Secret World of MicroRNAs
MicroRNAs (miRNAs) are tiny structures with enormous roles in gene expression regulation. They influence timed cell death (cell apoptosis), stem cell differentiation and metabolism, and can also be significant actors in virus infections, cancers, and neurodegeneration. Deciphering the molecular mechanisms of miRNA biogenesis may hold the key for future control of a plethora of medical conditions.
Prof Tuan Anh Nguyen’s research contributes to the understanding of the role of human Microprocessor complex in the maturation of miRNAs, using biochemical, structural, and bioinformatics approaches. The findings have extended previous knowledge of how human Microprocessor alone or with several cofactors accurately and efficiently process the primary miRNA transcripts to initiate miRNA maturation. In addition, he is investigating the links between miRNA production and virus amplification. One of his research projects is being funded for the next five years by the Croucher Innovation Award.
Prof Tuan Anh Nguyen is Assistant Professor of Life Science. He is a 2018 recipient of the Croucher Innovation Award.